Archive for the 'Uncategorized' Category

Presenting Millstone: Genome Engineering in the Cloud

Friday, March 21st, 2014

Next Tuesday we are unveiling Millstone, a web platform for genome engineering and analysis at the SynBERC 2014 Spring symposium. The product of a team led by myself and Gleb Kuznetsov, Millstone is the culmination of bioinformatics tool development that came out of the reColi project and other genome engineering efforts in the lab. Millstone […]

Using synthetic DNA to test genetic elements and improve gene expression

Friday, October 25th, 2013

We’ve recently published two papers involving the use of synthetic DNA libraries from microarrays. The first paper, published in The Proceedings of the National Academy of Sciences, details our work to build and test large libraries of synthetic genetic elements in high throughput. We developed a method called Flow-Seq, which combines next-generation sequencing and FACS […]

Removing a codon from E. coli

Saturday, July 16th, 2011

A new paper from the Church lab appears in July 15th’s issue of Science Magazine. I worked on aspects of this project during my initial rotation in the lab. In particular, I used conjugative assembly to combine together subunits of the modified genome (the CAGE method). I also led the genome re-sequencing effort. We sequenced […]

Joined the George Church Lab at Harvard Medical School

Monday, January 17th, 2011

As of July of 2010, I have finished my laboratory rotations and joined George Church’s lab at the Harvard Medical School Department of Genetics. I’m working in Dr. Church’s lab space at the Wyss Institute of Biologically Inspired Engineering across the river in Boston. My work in the Church lab will focus on manipulating bacterial […]

Classes and Rotations

Thursday, October 29th, 2009

Another update is in order, now that the semester is more than half-over. My HST courses are keeping me busy, and the fall weather here is turning colder by the day. The leaves are quite pretty though! I’ve started a rotation in the Ron Weiss lab, who has recently moved to MIT from Princeton University. […]

The Move to Boston

Thursday, September 10th, 2009

After nine months, a brief update is in order. My year-long Whitaker Fellowship at the University of Cambridge has now come to a close. It was a tremendous experience, and I’m grateful to have had the opportunity to pursue a variety of both computational and experimental research at Simon Tavaré’s lab at the Cambridge Research […]

New Year Updates

Wednesday, January 7th, 2009

The new year has rolled in, and a lot has happened. The 2008 iGEM summer project has come to a close. This November our Cambridge University team presented our Synthetic Biology project at the 2008 iGEM Jamboree at the Massachusetts Institute of Technology. We were working on several related projects involving bacterial self-organization. You can […]

iGEM Presentation, Cancer Research.

Sunday, October 26th, 2008

As my iGEM summer comes to a close, the team and I are finishing up work on our project and preparing to give a presentation at the 2008 iGEM Jamboree at MIT on November 8th, 2008. I am looking forward to giving my talk at MIT in a few weeks, meeting fellow iGEMers from across […]

Getting settled in Cambridge

Thursday, July 17th, 2008

After finishing my undergraduate studies this Spring, I spent two months travelling through Europe, mostly living in Barcelona. In July I relocated to Cambridge, UK. This summer I will be working with the 2008 Cambridge iGEM team. You can find more information about iGEM here, and visit out team wiki here. Starting in the Fall, […]

Daniel Bryan Goodman is currently an NSF Graduate Research Fellow at the Harvard-MIT Division of Health Sciences and Technology (HST). His current research involves technology development for synthetic and systems biology. He is synthesizing thousands of genes, globally modifying genomes, and interrogating the function of genetic elements in humans and model organisms for both clinical and basic research.